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Dystroglycan Adds More Sugars to the Midline Cocktail

In this issue of Neuron, Wright et al. (2012) identify two novel mediators of α-dystroglycan glycosylation in mouse and unravel a novel function of glycosylated dystroglycan in axon guidance by providing evidence for direct binding of α-DG to the midline chemorepellent Slit2.

Intensional HTML

Intensional HTML is a high-level Web authoring language that makes practical (using standard client and server software) the speci cation of pages and sites that exist in many di erent versions or variants. Each page of IHTML de nes an intension | an indexed family of actual (extensional) HTML pages which varies over a multi-dimensional author-speci ed version space. The version space is partia...

Tools for a More Efficient Airport

Embracing html.

As the field of chemical biology has grown, Nature Chemical Biology has expanded to reflect the diversity of science at the interface of chemistry and biology. Throughout this period, the editorial team has endeavored to publish leading research and thoughtful commentary across chemical biology and to present the field’s discoveries to the widest possible audience. As we enter our sixth volume,...

ROCKET AF adds more concerns about Digoxin safety in patients with atrial fibrillation

In a recent article in the Journal, we have reviewed the adverse cardiovascular outcomes observed with digoxin use in the PALLAS study.(1) The PALLAS study was designed to determine if dronedarone would reduce major vascular events in patients with permanent atrial fibrillation (AF).(2) However the study was stopped early because of safety reasons, as a significant number of patients on the dro...